Breast cancer risk models can be used to further stratify women in the familial risk category.

NCCN and ACS recommend consideration of annual breast MRI, in addition to mammogram for women with a >20% lifetime risk of breast cancer determined using a risk model largely dependent on family history.1,2

Breast cancer risk models can be used to further stratify women in the familial risk category.

NCCN and ACS recommend consideration of annual breast MRI, in addition to mammogram for women with a >20% lifetime risk of breast cancer determined using a risk model largely dependent on family history.1,2

Incorporating Tyrer-Cuzick will enable myRisk to provide a more comprehensive and precise assessment of a woman’s risk of breast cancer

The Tyrer-Cuzick Model:

Considers hormonal and pathologic risk factors in addition to family history

Incorporates negative BRCA1/2 results

Has been shown in independent studies to be one of the most consistently accurate models1,3

Tyrer-Cuzick Will Be Reported on the myRisk Management Tool

1

asterisk-icon General Medical Management Recommendations from NCCN Will Be Summarized for Women with a Tyrer-Cuzick Remaining Lifetime Breast Cancer Risk Estimate of ≥ 20%

2

Tyrer-Cuzick Risk is Reported as Remaining Lifetime and 5-Year Breast Cancer Risk Estimate

3

New Clinical and Cancer Family History Information page displays patient’s clinical and cancer family history as reported on the Test Request Form

A Tyrer-Cuzick Risk Estimate will be provided to women who are:

  • Unaffected by breast cancer
  • Negative for a breast cancer related gene mutation, and
  • Have no relatives with a known genetic mutation

NOTE: Version 7.02 of the Tyrer-Cuzick model will be used to provide a Tyrer-Cuzick risk estimate. Tyrer-Cuzick model Versions 7.02 and 8.0 are both available for download at the EMS-Trials website at http://www.ems-trials.org/riskevaluator

Myriad myRisk® Test Request Form (TRF) Updates

To learn more about Tyrer-Cuzick and its incorporation into myRisk, please watch the following learning module

References:

  1. Bevers, T et al. NCCN Clinical Practice Guidelines in Oncology: Breast Cancer Screening and Diagnosis. V 1.2016. July 27. Available at http://www.nccn.org.
  2. Saslow, D, Boetes C, Burke W, et al. American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin 2007;57:75-89. Available at http://www.ncbi.nlm.hih.gov/pubmed/17392385.
  3. Evans D, Howell, A. Breast cancer risk-assessment models. Breast Cancer Research. 2007;9:213.