March is Colon Cancer Awareness Month

Colorectal cancer is the second leading cause
of cancer deaths in the U.S.1

Approximately 135,430 people will be diagnosed with colorectal cancers in 2017.2
Approximately 50,260 people will die from colorectal cancer in 2017.2


Patients with a personal and/or family history of colon cancer may be at risk for hereditary cancer

Hereditary colorectal cancers account for approximately 3-5% of all colorectal cancers.3,4 Individuals with a hereditary cancer snydrome are at increased risk for developing an initial cancer as well as a second primary cancer in their lifetime. In fact, patients who have certain hereditary cancer syndromes may have up to a 99% risk of developing colorectal cancer by age 80.5 Therefore, it has become increasingly important to identify these patients in order to design accurate medical management options plans to reduce their risks.

*Hereditary cancer risk percentages are typically based on the gene mutation associated with the greatest cancer risk.

Colon Cancer Risk Graph 2017

Multiple genes are associated with hereditary colon cancer

Data presented at ASCO in June 2014 by Matthew Yurgelun, MD from Dana Farber illustrated that in 1,260 patients with clinical features suspicious for Lynch syndrome, 27% of the pathogenic mutations identified by the Myriad myRisk® hereditary cancer panel were outside of the genes associated Lynch syndrome.8

For more information about the data presented by Dr. Yurgelun:
See the data summary »

colon-gene-flower-16

Early detection of genetic mutations may help you prevent colon cancer or identify it at an earlier stage.9

Colon cancer is highly treatable if found and treated early. The 5-year survival rate for people with stage one colon cancer is approximately 90% as opposed to the survival rate for stage four colon cancers which is approximately 11%.10

Identify Patients in Your Practice at Risk for Hereditary Colon Cancer

Assessing Risk in Your Practice »

References

  1. Provenzale D, et al. NCCN Clinical Practice Guidelines in Oncology® Colorectal Cancer Screening. V 2.2016. October 20. Available at http://www.nccn.org.
  2. American Cancer Society. American Cancer Society Website: http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-key-statistics. Accessed January 9, 2017.
  3. Jasperson KW, et al. Hereditary and familial colon cancer. Gastroenterology. 2010; 138(6):2044-58.
  4. Meyer LA, et al. Obstet and Gyn. 2010; 115(5):945-52
  5. Giardiello FM, et al. AGA technical review on hereditary colorectal cancer and genetic testing. Gastroenterology. 2001:121:198-213.
  6. Surveillance Research Program, National Cancer Institute SEER*Stat software (seer.cancer.gov/seerstat) V 8.0.1, Nov 19, 2012.
  7. Weissman SM, et al. Genetic counseling considerations in the evaluation of families for Lynch syndrome–a review. Journal of Genetic Counseling. 2011; 20(1):5-19.
  8. Yurgulun, MB, et al. Identification of a variety of mutations in cancer predisposition genes in patients with suspected Lynch syndrome. Gastroenterology. 2015;149(3):604-13.
  9. Giardiello FM, et al. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastroenterology. 2014;147(2):502-26
  10. American Cancer Society. American Cancer Society Website: http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-survival-rates. Accessed February 11, 2016.

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